Publication Type Journal Article
Title Study of the molecular mobility of (+/-)-methocarbamol in the amorphous solid state
Authors J. J. Moura-Ramos H. P. Diogo
Groups
Journal EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS
Year 2017
Month April
Volume 226
Number 5
Pages 889-904
Abstract The experimental techniques of differential scanning calorimetry (DSC) and thermally stimulated depolarization currents (TSDC) were used to study the thermal behavior of the pharmaceutical drug (+/-)-methocarbamol and its slow molecular mobility (in the 10(-3)-10(-2) Hz range) in the amorphous solid state. The possibility of polymorphism was considered based on the DSC results. The glass forming ability and the glass stability were investigated by DSC, and the general kinetic features of the main relaxation, including the fragility or steepness index, were studied by both experimental techniques. The secondary relaxations detected by TSDC revealed fast and slow (Johari-Goldstein) modes. These secondary relaxations of different nature were assigned based on physical aging studies.
DOI http://dx.doi.org/10.1140/epjst/e2016-60233-y
ISBN
Publisher SPRINGER HEIDELBERG
Book Title
ISSN 1951-6355
EISSN 1951-6401
Conference Name
Bibtex ID ISI:000399817700008
Observations
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