Publication Type Journal Article
Title New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy
Authors M. Helena Garcia Andreia Valente Pedro Florindo Tânia S. Morais M.Fatima M.Piedade M. Teresa Duarte Virtudes Moreno Francesc X. Aviles Julia Loreno
Groups BIOIN BioMol
Journal INORGANICA CHIMICA ACTA
Year 2010
Month November
Volume 363
Number 14
Pages 3765-3775
Abstract A new family of Ru(II) mixed metallocene complexes of the type [Ru(eta(5)-C5H5)(eta(6)-arene)][PF6] has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for all the complexes and revealed the presence of two enantiomers expected for planar chirality originated by the eta(6) coordination of the arene prochiral ligands. Studies of interaction of the new complexes with pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed low antiproliferative activity compared to cisplatin. (c) 2010 Elsevier B. V. All rights reserved.
DOI http://dx.doi.org/10.1016/j.ica.2010.05.034
ISBN
Publisher ELSEVIER SCIENCE SA
Book Title
ISSN 0020-1693
EISSN
Conference Name
Bibtex ID ISI:000283051600019
Observations
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