| Publication Type |
Journal Article |
| Title |
PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation |
| Authors |
Joana Teles Ferreira Joao Pina Carlos Alberto Fontes Ribeiro Rosa Fernandes João P. C. Tomé M. Salome Rodriguez-Morgade Tomas Torres |
| Groups |
CCC |
| Journal |
JOURNAL OF MATERIALS CHEMISTRY B |
| Year |
2017 |
| Month |
August |
| Volume |
5 |
| Number |
29 |
| Pages |
5862-5869 |
| Abstract |
Three ruthenium(II) phthalocyanines functionalized at their axial positions with 4-12 PEG chains bearing hydroxy, amino and ether terminal groups were synthesized and studied as PDT agents against bladder cancer cells. All three dyes displayed high singlet oxygen generation quantum yields in DMSO (Phi Delta = 0.76). The water-soluble Ru(L3)(2)Pc also shows high singlet oxygen quantum yields (Phi Delta = 0.48) in neat water. In vitro studies show that these complexes are accumulated in bladder cancer cells, are nontoxic PSs per se, and have high phototoxic efficiency. |
| DOI |
http://dx.doi.org/10.1039/c7tb00958e |
| ISBN |
|
| Publisher |
ROYAL SOC CHEMISTRY |
| Book Title |
|
| ISSN |
2050-750X |
| EISSN |
2050-7518 |
| Conference Name |
|
| Bibtex ID |
ISI:000406616400017 |
| Observations |
|
