| Publication Type |
Journal Article |
| Title |
Synthesis, antimicrobial activity and toxicity to nematodes of cyclam derivatives |
| Authors |
Luis G. Alves Pedro F. Pinheiro Joana R. Feliciano Diana P. Damaso Jorge H. Leitao Ana M. Martins |
| Groups |
IOARC BioMol |
| Journal |
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS |
| Year |
2017 |
| Month |
May |
| Volume |
49 |
| Number |
5 |
| Pages |
646-649 |
| Abstract |
The antimicrobial activity and toxicity to nematodes of the cyclam salt [H-2\H-2(4-CF3PhCH2)(2)Cyclam\](CH3COO)(2)center dot(CH3COOH)(2) were evaluated. Estimated minimum inhibitory concentrations (MICs) of 9, 261 and 15 mu g/mL were obtained for Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, respectively. For selected Candida spp., the estimated MICs obtained ranged from 32 mu g/mL to 63 mu g/mL. Bactericidal activity was demonstrated but the compound was not reliably fungicidal. Concentrations of the cyclam salt up to 32 mu g/mL did not significantly affect survival of the nematode Caenorhabditis elegans; however, concentrations equal or above this value significantly affected nematode survival in a dose-dependent manner. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved. |
| DOI |
http://dx.doi.org/10.1016/j.ijantimicag.2017.03.002 |
| ISBN |
|
| Publisher |
ELSEVIER SCIENCE BV |
| Book Title |
|
| ISSN |
0924-8579 |
| EISSN |
1872-7913 |
| Conference Name |
|
| Bibtex ID |
ISI:000402467500020 |
| Observations |
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