Publication Type Journal Article
Title The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds
Authors Leonor Côrte-Real M Paula Robalo Fernanda M. Marques Guilherme Nogueira Fernando Avecilla Tiago J. L. Silva Filipa C. Santos Ana Isabel Tomaz M. Helena Garcia Andreia Valente
Groups BIOIN BioMol
Journal JOURNAL OF INORGANIC BIOCHEMISTRY
Year 2015
Month September
Volume 150
Number
Pages 148-159
Abstract A new family of eight ruthenium(II)-cyclopentadienyl bipyridine derivatives, bearing nitrogen, sulfur, phosphorous and carbonyl sigma bonded coligands, has been synthesized. Compounds bearing nitrogen bonded coligands were found to be unstable in aqueous solution, while the others presented appropriate stabilities for the biologic assays and pursued for determination of IC50 values in ovarian (A2780) and breast (MCF7 and MDAMB231) human cancer cell lines. These studies were also carried out for the [5: HSA] and [6: HSA] adducts (HSA = human serum albumin) and a better performance was found for the first case. Spectroscopic, electrochemical studies by cyclic voltammetry and density functional theory calculations allowed us to get some understanding on the electronic flow directions within the molecules and to find a possible clue concerning the structural features of coligands that can activate bipyridyl ligands toward an increased cytotoxic effect. X-ray structure analysis of compound [Ru(eta(5)-C5H5)(bipy)(PPh3)][PF6] (7; bipy = bipyridine) showed crystallization on C2/c space group with two enantiomers of the [Ru(eta(5)-C5H5)(bipy)(PPh3)](+) cation complex in the racemic crystal packing. (C) 2015 Elsevier Inc All rights reserved.
DOI http://dx.doi.org/10.1016/j.jinorgbio.2015.06.015
ISBN
Publisher ELSEVIER SCIENCE INC
Book Title
ISSN 0162-0134
EISSN 1873-3344
Conference Name
Bibtex ID ISI:000366344800017
Observations
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