Publication Type Journal Article
Title Antiparasitic Activity of Diterpenoids Against Trypanosoma cruzi
Authors Sergio Alegre-Gomez Paula Sainz M. Fatima Simoes Patricia Rijo C. M. M. Moiteiro Azucena Gonzalez-Coloma Rafael A. Martinez-Diaz
Groups HC
Journal PLANTA MEDICA
Year 2017
Month February
Volume 83
Number 3
Pages 306-311
Abstract Twenty-seven diterpenes, including abietanes, labdanes, abeoabietanes, halimanes, and pimaranes, have been evaluated against epimastigote and intracellular amastigote forms of Trypanosoma cruzi and also against LC5 and NCTC cell lines. Royleanones (3, 4, and 5) and a further abietane (12), obtained by purification of Plectranthus spp. extracts, were the most active compounds on epimastigotes, showing IC50 values similar (1.73 mu g/mL, 12) or even lower (0.39, 0.99, and 1.20 mu g/mL, 3, 4, and 5 respectively) than the positive control nifurtimox (2.3 mu g/mL). On intracellular amastigotes, abietanes 3, 4, and 5 showed a significant activity with IC50 values of 0.83, < 0.31, and 0.62 mu g/mL, respectively, but were less potent than the positive control nifurtimox (IC50 < 0.16 mu g/mL). Compounds 3, 4, and 5 were not cytotoxic to LC5 and NCTC 929 cells at 1 mu g/mL.
DOI http://dx.doi.org/10.1055/s-0042-115646
ISBN
Publisher
Book Title
ISSN 0032-0943
EISSN 1439-0221
Conference Name
Bibtex ID ISI:000397029700016
Observations
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