| Publication Type |
Journal Article |
| Title |
Direct experimental observation of the aggregation of alpha-amino acids into 100-200 nm clusters in aqueous solution |
| Authors |
Daniel Hagmeyer Johannes Ruesing Tassilo Fenske Heinz-Werner Klein Carsten Schmuck Wolfgang Schrader M. E. M. Piedade Matthias Epple |
| Groups |
MET |
| Journal |
RSC ADVANCES |
| Year |
2012 |
| Month |
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|
| Volume |
2 |
| Number |
11 |
| Pages |
4690-4696 |
| Abstract |
Spherical supramolecular aggregates of alpha-amino acids with a typical diameter of 100-200 nm are formed spontaneously after dissolution in water at a concentration of a few mM, i.e. well below the solubility limit. Their presence was shown by nanoparticle tracking analysis (NTA), atomic force microscopy (AFM), and ESI mass spectrometry (ESI-MS). There is a dynamic equilibrium between the aggregates and dissolved individual molecules which allows them to penetrate through dialysis membranes and filters. The same phenomenon was observed for para-amino salicylic acid and two dipeptides. Thermodynamic considerations suggest an entropy-controlled process. |
| DOI |
http://dx.doi.org/10.1039/c2ra01352e |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
2046-2069 |
| EISSN |
|
| Conference Name |
|
| Bibtex ID |
ISI:000304148400022 |
| Observations |
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