Publication Type Journal Article
Title Organocatalyzed oxidation of benzyl alcohols by a tetrazole-amino-saccharin: A combined experimental and theoretical (DFT) study
Authors Luís M. T. Frija Maxim L. Kuznetsov Bruno G. M. Rocha Lilia Cabral M. Lurdes S. Cristiano Maximilian N. Kopylovich Armando J.L. Pombeiro
Groups CCC
Journal MOLECULAR CATALYSIS
Year 2017
Month December
Volume 442
Number
Pages 57-65
Abstract A new catalytic system for the anaerobic oxidation of benzyl alcohols using a tetrazole-amino-saccharin organocatalyst has been established. In a solvent-free and microwave assisted process comprising aqueous tert-butyl hydroperoxide (TBHP) as oxidant, a variety of benzyl alcohols has been efficiently converted to aldehydes under mild conditions. Most reactions are complete within 30 min and the catalyst exhibits varied functional group compatibility. A catalytic cycle for the oxidation of the alcohols promoted by the tetrazole-amino-saccharin derivative is outlined involving radical species. DFT calculations performed for the oxidation of benzyl alcohol with and without organocatalyst show that the rate limiting step of the whole reaction is the cleavage of the O-O bond in TBHP with the subsequent hydrogen abstraction from the alcohol. The tetrazole-amino-saccharin organocatalyst assists the H-abstraction from benzyl alcohol by the bound HO center dot radical. The simplicity, selectivity and softness of reaction conditions of the studied organocatalytic protocol suggest a great potential for extensive use in synthetic chemistry. (C) 2017 Elsevier B.V. All rights reserved.
DOI http://dx.doi.org/10.1016/j.mcat.2017.09.003
ISBN
Publisher
Book Title
ISSN 2468-8231
EISSN
Conference Name
Bibtex ID ISI:000415773200007
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