| Publication Type |
Journal Article |
| Title |
Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells |
| Authors |
Ricardo G. Teixeira Ana Rita Brás Leonor Côrte-Real Rajendhraprasad Tatikonda Anabela Sanches M Paula Robalo Fernado Avecilla Tiago Moreira M. Helena Garcia Matti Haukka Ana Preto Andreia Valente |
| Groups |
BIOIN |
| Journal |
European Journal of Medicinal Chemistry |
| Year |
2018 |
| Month |
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| Volume |
143 |
| Number |
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| Pages |
503-514 |
| Abstract |
Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(h5-MeCp)(PPh3)2Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(h5-MeCp)(PPh3)(L1)][CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4e6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent. |
| DOI |
http://dx.doi.org/https://doi.org/10.1016/j.ejmech.2017.11.059 |
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