| Publication Type |
Journal Article |
| Title |
Intramolecular C-H insertion catalyzed by dirhodium(II) complexes using CO2 as the reaction media |
| Authors |
M.E. Zakrzewska P.M.S.D. Cal N.R. Candeias R. Bogel-Lukasik C.A.M. Afonso M.N. Ponte P.M.P. Gois |
| Groups |
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| Journal |
Green Chemistry Letters and Reviews |
| Year |
2012 |
| Month |
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| Volume |
5 |
| Number |
2 |
| Pages |
211-240 |
| Abstract |
In this work, the intramolecular C-H insertion of diazoacetamides catalyzed by dirhodium(II) complexes and using CO2 as solvent is disclosed. The expected lactams were obtained in yields over 97%. The asymmetric intramolecular C-H insertion was also achieved and the beta-lactam 14 was obtained in > 97% yield and 65% ee using the chiral dirhodium(II) catalyst Rh-2(S-PTTL)(4). Finally, the dirhodium(II) complex Rh-2(OAc)(4) was used in two consecutive cycles in which complete conversion to the lactam was observed. |
| DOI |
http://dx.doi.org/10.1080/17518253.2011.620009 |
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