| Publication Type |
Journal Article |
| Title |
A Sustainable Synthesis of Asymmetric Phenazines and Phenoxazinones Mediated by CotA-Laccase |
| Authors |
Ana Catarina Cardoso de Sousa M. Conceição Oliveira Ligia O. Martins M Paula Robalo |
| Groups |
BioMol |
| Journal |
ADVANCED SYNTHESIS \& CATALYSIS |
| Year |
2018 |
| Month |
February |
| Volume |
360 |
| Number |
3 |
| Pages |
575-583 |
| Abstract |
An efficient and sustainable one-step procedure for the synthesis of new asymmetric phenazines and phenoxazinones from commercially available ortho-substituted diamines and ortho-substituted hydroxyamines is reported. In this study we have expanded the substrate scope of CotA-laccase-catalyzed aerobic oxidations through the use of aromatic amines presenting variable functional groups, including N-substitution, contributing to the rational synthesis of different heterocyclic scaffolds. The transformations proceed smoothly through a cascade of oxidative reactions to the benzoquinonediimine intermediates followed by nucleophilic addition, intramolecular cyclization and aromatization, all performed in mild conditions. |
| DOI |
http://dx.doi.org/10.1002/adsc.201701228 |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
1615-4150 |
| EISSN |
1615-4169 |
| Conference Name |
|
| Bibtex ID |
ISI:000424093900028 |
| Observations |
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