| Abstract |
Nalidixic acid is an antibiotic from the quinolones family whose bioavailability is limited due to its low solubility. The development of complexes and bioinspired metal-organic frameworks has been explored as a way to achieve controlled drug delivery and release, and we demonstrate that they can also be used to tune drugs physicochemical properties, such as solubility. Herein we disdose a series of complexes and frameworks of nalidixic acid and Zn. One of these frameworks duplicates the solubility of nalidixic acid, and it is stable on the shelf and to 77\% room humidity. The incorporation of a second ligand into the frameworks is also presented, showing the possibility to develop extended networks with further potential applications. |
