| Publication Type |
Journal Article |
| Title |
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity |
| Authors |
Marilena Tauro Antonio Laghezza Fulvio Loiodice Luca Piemontese Alessia Caradonna Davide Capelli Roberta Montanari Giorgio Pochetti Antonella Di Pizio Mariangela Agamennone Cristina Campestre Paolo Tortorella |
| Groups |
|
| Journal |
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY |
| Year |
2016 |
| Month |
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|
| Volume |
31 |
| Number |
4 |
| Pages |
25-37 |
| Abstract |
New catechol-containing chemical entities have been investigated as matrix metalloproteinase inhibitors as well as antioxidant molecules. The combination of the two properties could represent a useful feature due to the potential application in all the pathological processes characterized by increased proteolytic activity and radical oxygen species (ROS) production, such as inflammation and photoaging. A series of catechol-based molecules were synthesized and tested for both proteolytic and oxidative inhibitory activity, and the detailed binding mode was assessed by crystal structure determination of the complex between a catechol derivative and the matrix metalloproteinase-8. Surprisingly, X-ray structure reveals that the catechol oxygens do not coordinates the zinc atom. |
| DOI |
http://dx.doi.org/10.1080/14756366.2016.1217853 |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
1475-6366 |
| EISSN |
1475-6374 |
| Conference Name |
|
| Bibtex ID |
ISI:000391904900004 |
| Observations |
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