| Publication Type |
Journal Article |
| Title |
Synthesis of a Biologically Active Oxazol-5-(4H)-one via an Erlenmeyer-Plochl Reaction |
| Authors |
C. Rodrigues J. M. G. Martinho Carlos A. M. Afonso |
| Groups |
|
| Journal |
JOURNAL OF CHEMICAL EDUCATION |
| Year |
2015 |
| Month |
September |
| Volume |
92 |
| Number |
9 |
| Pages |
1543-1546 |
| Abstract |
The synthesis of (Z)-4-(4-nitrobenzylidene)-2-phenyloxazol-5(4H)-one, which is a potent immunomodulator and tyrosinase inhibitor, is described as an experiment for an upper-division undergraduate organic chemistry laboratory course. This compound is produced via an Erlenmeyer-Plochl reaction in the absence Of any additional solvents and is isolated without need of preparative chromatography, yielding up to 97\% of product. |
| DOI |
http://dx.doi.org/10.1021/ed500212t |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
0021-9584 |
| EISSN |
1938-1328 |
| Conference Name |
|
| Bibtex ID |
ISI:000361580200020 |
| Observations |
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