| Publication Type |
Journal Article |
| Title |
3-hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use |
| Authors |
M. Amélia Santos Sílvia Chaves |
| Groups |
|
| Journal |
FUTURE MEDICINAL CHEMISTRY |
| Year |
2015 |
| Month |
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|
| Volume |
7 |
| Number |
3 |
| Pages |
383-410 |
| Abstract |
Although iron is one of the most important metal ions for living organisms, it becomes toxic when in excess or misplaced. This review presents a glance at representative examples of hydroxypyridinone-based chelators, which have been recently developed as potential clinically useful drugs for metal overload diseases, mostly associated with excess of iron but also other hard metal-ions. It also includes a detailed discussion on the factors assisting chelator design strategy toward fulfillment of the most relevant biochemical properties of hydroxypyridinone chelators, highlighting structure-activity relationships and a variety of potential clinical applications, beyond chelatotherapy. This study appears as a response to the growing interest on metal chelation therapy and opens new perspectives of possible applications in future medicine. |
| DOI |
http://dx.doi.org/10.4155/FMC.14.162 |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
1756-8919 |
| EISSN |
1756-8927 |
| Conference Name |
|
| Bibtex ID |
ISI:000362888800009 |
| Observations |
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