| Publication Type |
Journal Article |
| Title |
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators |
| Authors |
Luca Piemontese Antonio Laghezza Giuseppe Fracchiolla Giuseppe Carbonara Paolo Tortorella Fulvio Loiodice |
| Groups |
|
| Journal |
TETRAHEDRON-ASYMMETRY |
| Year |
2013 |
| Month |
July |
| Volume |
24 |
| Number |
13 |
| Pages |
791-795 |
| Abstract |
2H-1,4-Benzoxazine amidine derivatives are drugs acting as modulators of the skeletal muscle and pancreatic beta cell ATP-sensitive-K+ (KATP) channels. With the aim of evaluating the influence of absolute configuration on the biological activity of these drugs, we herein report the optimization of a synthetic route to obtain both enantiomers of some of these compounds with improved chemical yield and high enantiomeric excess. (C) 2013 Elsevier Ltd. All rights reserved. |
| DOI |
http://dx.doi.org/10.1016/j.tetasy.2013.05.027 |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
0957-4166 |
| EISSN |
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| Conference Name |
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| Bibtex ID |
ISI:000322610500003 |
| Observations |
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