Publication Type Journal Article
Title Pd-Catalyzed Direct C-H Alkenylation and Allylation of Azine N-Oxides
Authors Fares Roudesly Luis F. Veiros Julie Oble Giovanni Poli
Groups IOARC
Journal ORGANIC LETTERS
Year 2018
Month April
Volume 20
Number 8
Pages 2346-2350
Abstract A Pd-catalyzed direct C-2-alkenylation of azine N-oxides with allyl acetate is disclosed. The products are formed through an allylation/isomerization cascade process. The use of a tri-tert-butylphosphonium salt as the ligand precursor and KF is mandatory for optimal yields. When cinnamyl acetate is used, the same catalytic system promotes C-2-cinnamylation of the azine N-oxide without subsequent isomerization. A mechanism is proposed on the basis of experimental studies and DFT calculations.
DOI http://dx.doi.org/10.1021/acs.orglett.8b00689
ISBN
Publisher
Book Title
ISSN 1523-7060
EISSN 1523-7052
Conference Name
Bibtex ID ISI:000430898200051
Observations
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