Publication Type Journal Article
Title Synthesis and Characterization of Isosorbide-Based Polyurethanes Exhibiting Low Cytotoxicity Towards HaCaT Human Skin Cells
Authors Barbara S. Gregori Valdes Clara S. B. Gomes Pedro T. Gomes Jose R. Ascenso H. P. Diogo Lidia M. Goncalves Rui Galhano dos Santos Helena M. Ribeiro Joao C. Bordado
Groups IOARC
Journal POLYMERS
Year 2018
Month October
Volume 10
Number 10
Pages
Abstract The synthesis of four samples of new polyurethanes was evaluated by changing the ratio of the diol monomers used, poly(propylene glycol) (PPG) and D-isosorbide, in the presence of aliphatic isocyanates such as the isophorone diisocyanate (IPDI) and 4,4-methylenebis(cyclohexyl isocyanate) (HMDI). The thermal properties of the four polymers obtained were determined by DSC, exhibiting T-g values in the range 55-70 degrees C, and their molecular structure characterized by FTIR, H-1, and C-13 NMR spectroscopies. The diffusion coefficients of these polymers in solution were measured by the Pulse Gradient Spin Echo (PGSE) NMR method, enabling the calculation of the corresponding hydrodynamic radii in diluted solution (1.62-2.65 nm). The molecular weights were determined by GPC/SEC and compared with the values determined by a quantitative C-13 NMR analysis. Finally, the biocompatibility of the polyurethanes was assessed using the HaCaT keratinocyte cell line by the MTT reduction assay method showing values superior to 70\% cell viability.
DOI http://dx.doi.org/10.3390/polym10101170
ISBN
Publisher
Book Title
ISSN 2073-4360
EISSN
Conference Name
Bibtex ID ISI:000448662400125
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