Abstract |
Saccharin (SacH) reacts with the dialkylcyanamides NCNR2 (R-2 = Me-2, Et-2, C4H8, C5H10, and C4H8O) to grant the guanidinated saccharin derivatives Sac-C(C6H4-2-SO3-H)NC+(NH2)NR2 (65-91\%) generated via three-component integration; this type of reactivity has never been observed before for saccharin or any of the nitrile substrates. |