Publication Type Journal Article
Title Organoruthenium(II) nucleoside conjugates as colon cytotoxic agents
Authors Pedro R. Florindo Diane M. Pereira Pedro M. Borralho M. F. M. Piedade M. Conceição Oliveira Ana M. Dias Cecilia M. P. Rodrigues A C Fernandes
Groups BIOMOL
Journal NEW JOURNAL OF CHEMISTRY
Year 2019
Month January
Volume 43
Number 3
Pages 1195-1201
Abstract Eleven ruthenium-nucleoside conjugates with the general formula [(eta(5)-C5H5)Ru(PP)L][PF6] (PP = 1,2-bis(diphenylphosphino)ethane (Dppe), 2PPh(3), and L = 3-N-(p-cyanobenzyl)thymidine derivative ligand) are reported. Both [(eta(5)-C5H5)Ru(Dppe)N C-R](+) and [(eta(5)-C5H5)Ru(PPh3)(2)N C-R](+) scaffolds exhibit remarkable stability towards hydrolysis. Compounds show high cytotoxicity in HCT116 colon cancer cells, with IC50 values down to 1.0 mu M. Uptake competition experiments with 2 -deoxyadenosine revealed its cellular absorption to be independent of nucleoside transporters.
DOI http://dx.doi.org/10.1039/c8nj04515a
ISBN
Publisher
Book Title
ISSN 1144-0546
EISSN 1369-9261
Conference Name
Bibtex ID ISI:000459941000011
Observations
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