Publication Type Journal Article
Title Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities
Authors Hicham Zaidi Salim Ouchemoukh Nadia Amessis-Ouchemoukh Nadjet Debbache Rita Pacheco Maria L. Serralheiro M. Eduarda Araújo
Groups HC
Journal EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
Year 2019
Month January
Volume 25
Number
Pages 77-84
Abstract Introduction: Honey is used in various cultures as a traditional medicine and folkloric treatment. The aim of this study was to determine the antioxidant and the anti-inflammatory activities of 31 Algerian honeys and acetylcholinesterase (AChE) and alpha-glucosidase inhibitory activities of phenolic compounds extracts of these honeys. Methods: The anti-inflammatory activity of honey was evaluated by the method of inhibition of BSA (Bovin Serum Albumin) heat-induced denaturation. The inhibition of AChE and alpha-glucosidase by the honey extracts was evaluated by in-vitro methods. Results: The highest percentage of inhibition (85.33\%) of BSA denaturation was obtained with polyfloral honey (H27). Radical scavenging activity of honey samples against 1,1-diphenyl-2-picrilhydrazyl (DPPH), and 2,2 -azinobis(-3) -ethylbenzothiazoline-6-sulfonic acid (ABTS) varied from 4.41 to 83.93\% and from 2.52 to 63.24\%, respectively. AChE inhibitory activity is one target to prevent neurodegenerative damage in Alzheimer s disease. AChE inhibition recorded values from 20.69 to 76.04\%. alpha-glucosidase inhibitors such as acarbose is preconized for the control of hyperglycemia and prevent diabetes damages. Honey extracts demonstrated a significant inhibitory effect on alpha-glucosidase activity. Moreover, the effect of Fabacece honey (H19) (IC50 = 52.20 mu g/mL) was found to be more potent than acarbose (IC50 = 204.27 mu g/mL). Correlations were observed between antioxidants and anti-inflammatory activities, AChE and alpha-glucosidase inhibitions with total phenolic compounds and flavonoids content in honey samples. Conclusion: This study showed that honey could be exploited as a potential antioxidant and anti-inflammatory agent within therapeutic medicine.
DOI http://dx.doi.org/10.1016/j.eujim.2018.11.008
ISBN
Publisher
Book Title
ISSN 1876-3820
EISSN 1876-3839
Conference Name
Bibtex ID ISI:000456724400012
Observations
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