Publication Type Journal Article
Title Solving a sticking related tablet problem by multivariate statistics and computational tomographic analysis
Authors Nuno F. Costa Mario G. Paulo H. P. Diogo Joao F. Pinto
Groups BioMol
Journal POWDER TECHNOLOGY
Year 2020
Month May
Volume 367
Number
Pages 456-463
Abstract This work identifies the cause of sticking of granules in an industrial process of tableting. Retrospective multivariate statistical analysis of industrial scale batches records (PLS, properties and manufacturing conditions of granules and tablets) identified the air flow rate in both granulation and drying operations as the critical parameter impacting on sticking. Scaling down the manufacture of tablets to the laboratory scale has allowed the evaluation of the granules behaviour, that have deformed and fragmented (main mechanism), while converting into tablets. Fragments of granules with high water content in their cores (>2.20\%, confirmed by tomography) promoted the sticking of tablets to both dies and punches. In conclusion, the combination of a retrospective analysis of batch records, combined with complementary analysis in the laboratory enabled the identification of the cause of sticking with an increase on manufacture yield from ca 78\% in many batches up to >98\% for all batches. (C) 2020 Elsevier B.V. All rights reserved.
DOI http://dx.doi.org/10.1016/j.powtec.2020.03.063
ISBN
Publisher
Book Title
ISSN 0032-5910
EISSN 1873-328X
Conference Name
Bibtex ID ISI:000532835500044
Observations
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