Publication Type Journal Article
Title Synthesis, Characterization and Anticancer Studies of Rh(I), Rh(III), Pd(II) and Pt(II) Complexes Bearing A Dithiooxamide Ligand
Authors Banafshe Askari Hadi Amiri Rudbari Andreia Valente Giuseppe Bruno Nicola Micale Naveen Shivalingegowda Lokanath Neratur Krishnappagowda
Groups BIOIN
Journal CHEMISTRYSELECT
Year 2020
Month January
Volume 5
Number 2
Pages 810-817
Abstract Breast cancer is the most common type of cancer in women. In the current study, six transition-metal complexes were reacted with a secondary dithiooxamide (H-2-isopropyl(2)DTO) to obtain the corresponding mononuclear complexes (1-6) and their cytotoxicity was evaluated in two human breast cancer cell lines, i. e. MCF-7 and MDA-MB-231. The characterization of the complexes, [LnM(H-isopropyl(2) DTO kappa-S,S M)] (LnM=(C5Me5)RhCl, (1); (COD)Rh, (2); (eta(3)-allyl)Pd, (3); (tri(n)propyl-phosphine)PdCl, (4); (bpy)Pt, (5) and (pph(3))PtCl, (6)), and the ion pair form of 1-4, IP1-IP4, were accomplished through NMR spectroscopy and elemental analysis. The structures of 1 and IP1 were also determined by single crystal XRD technique. In vitro cytotoxicity studies in MCF-7 and MDA-MB-231 (IC50 determination) showed that all complexes are cytotoxic for both cell lines, with the exception of 2. Compound 3 was the most cytotoxic in the conditions tested. In addition, the compounds induce cell death by apoptosis and inhibit the formation of colonies, indicating that these compounds could provide promising new lead derivatives for anticancer drug development.
DOI http://dx.doi.org/10.1002/slct.201903939
ISBN
Publisher
Book Title
ISSN 2365-6549
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Conference Name
Bibtex ID ISI:000507660100046
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