Publication Type Journal Article
Title Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine
Authors Maria Joao Correia Antonio B. Pimpao Dalila G. F. Fernandes Judit Morello Catarina O. Sequeira Joaquim Calado Alexandra Maria Moita Antunes Manuel S. Almeida Patricia Branco Emilia C. Monteiro Joao B. Vicente Jacinta Serpa Sofia A. Pereira
Groups BioMol
Journal MOLECULES
Year 2022
Month
Notice: Undefined index: in /afs/ist.utl.pt/groups/cqe/web/tmp/templates_c/77f86a5f762542dadf50c7f7fefa96acd45c2726_0.file.paper.tpl.html.php on line 163
Volume 27
Number 4
Pages
Abstract In this review encouraged by original data, we first provided in vivo evidence that the kidney, comparative to the liver or brain, is an organ particularly rich in cysteine. In the kidney, the total availability of cysteine was higher in cortex tissue than in the medulla and distributed in free reduced, free oxidized and protein-bound fractions (in descending order). Next, we provided a comprehensive integrated review on the evidence that supports the reliance on cysteine of the kidney beyond cysteine antioxidant properties, highlighting the relevance of cysteine and its renal metabolism in the control of cysteine excess in the body as a pivotal source of metabolites to kidney biomass and bioenergetics and a promoter of adaptive responses to stressors. This view might translate into novel perspectives on the mechanisms of kidney function and blood pressure regulation and on clinical implications of the cysteine-related thiolome as a tool in precision medicine.
DOI http://dx.doi.org/10.3390/molecules27041416
ISBN
Publisher
Book Title
ISSN
EISSN 1420-3049
Conference Name
Bibtex ID WOS:000764341700001
Observations
Back to Publications List