Bioactivity of Isostructural Hydrogen Bonding Frameworks Built from Pipemidic Acid Metal Complexes
MOLECULES, 25, 5 2020
Paula C. Alves , Patricia Rijo , Catarina Bravo , Alexandra Maria Moita Antunes , Vânia André

Novel Antibacterial Azelaic Acid BioMOFs
CRYSTAL GROWTH \& DESIGN, 20, 370-382 1 2020
Silvia Quaresma , Vânia André , Alexandra Maria Moita Antunes , Sergio M. F. Vilela , Georgiana Amariei , Ana Arenas-Vivo , Roberto Rosal , Patricia Horcajada , M. Teresa Duarte

Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21, 6 2020
Madalena Cipriano , Pedro F. Pinheiro , Catarina O. Sequeira , Joana S. Rodrigues , Nuno G. Oliveira , Alexandra Maria Moita Antunes , Matilde Castro , M. Matilde Marques , Sofia A. Pereira , Joana P. Miranda

Severe Acute Kidney Injury and Double Tubulopathy Due to Dual Toxicity Caused by Combination Antiretroviral Therapy
KIDNEY INTERNATIONAL REPORTS, 4, 494-499 3 2019
Karina Soto , Pedro Campos , Rita Manso , Alexandra Maria Moita Antunes , Judit Morello , Mark A. Perazella

Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study
CHEMICAL RESEARCH IN TOXICOLOGY, 32, 869-877 5 2019
Aline de Conti , Volodymyr Tryndyak , Linda S. VonTungeln , Mona I. Churchwell , Frederick A. Beland , Alexandra Maria Moita Antunes , Igor P. Pogribny

Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity
DRUG METABOLISM REVIEWS, 51, 76-90 1 2019
Aline T. Marinho , Joana P. Miranda , Umbelina Caixas , Catarina Charneira , Clara Goncalves-Dias , M. Matilde Marques , Emilia C. Monteiro , Alexandra Maria Moita Antunes , Sofia A. Pereira

Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease
NEPHRON, 143, 17-23 2019
Clara Goncalves-Dias , Judit Morello , M. Joao Correia , Nuno R. Coelho , Alexandra Maria Moita Antunes , Maria Paula de Macedo , Emilia C. Monteiro , Karina Soto , Sofia A. Pereira

Targeting Glutathione and Cystathionine beta-Synthase in Ovarian Cancer Treatment by Selenium-Chrysin Polyurea Dendrimer Nanoformulation
NUTRIENTS, 11, 10 2019
Ines Santos , Cristiano Ramos , Cindy Mendes , Catarina O. Sequeira , Catarina S. Tome , Dalila G. H. Fernandes , Pedro Mota , Rita F. Pires , Donato Urso , Ana Hipolito , Alexandra Maria Moita Antunes , Joao B. Vicente , Sofia A. Pereira , Vasco D. B. Bonifacio , Sofia C. Nunes , Jacinta Serpa

A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications
FRONTIERS IN CHEMISTRY, 7, 7 2019
Joao Nunes , Catarina Charneira , Carolina Nunes , Sofia Gouveia-Fernandes , Jacinta Serpa , Judit Morello , Alexandra Maria Moita Antunes

The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals
FREE RADICAL BIOLOGY AND MEDICINE, 129, 559-568 12 2018
Ines L. Martins , Joao Nunes , Catarina Charneira , Judit Morello , Sofia A. Pereira , J. P. Telo , M. Matilde Marques , Alexandra Maria Moita Antunes

Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 105, 47-54 7 2017
Nadia M. Grilo , M. Joao Correia , Joana P. Miranda , Madalena Cipriano , Jacinta Serpa , M. Matilde Marques , Emilia C. Monteiro , Alexandra Maria Moita Antunes , Lucilia N. Diogo , Sofia A. Pereira

Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study
ARCHIVES OF TOXICOLOGY, 91, 1199-1211 3 2017
Pedro F. Pinheiro , Sofia A. Pereira , Shrika G. Harjivan , Inês Sofia Lança Martins , Aline T. Marinho , Madalena Cipriano , Cristina C. Jacob , Nuno G. Oliveira , Matilde F. Castro , M. Matilde Marques , Alexandra Maria Moita Antunes , Joana P. Miranda

Integration of cellular and molecular endpoints to assess the toxicity of polycyclic aromatic hydrocarbons in HepG2 cell line
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 36, 3404-3414 12 2017
Patricia I. Morgado , Silvia Jose , Riccardo Wanke , Alexandra Maria Moita Antunes , Ana Sofia Cardoso , Luisa Jordao

New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan
TOXICOLOGY LETTERS, 264, 106-113 12 2016
Joao Nunes , Inês Sofia Lança Martins , Catarina Sofia Romão Charneira , Igor P. Pogribny , Aline de Conti , Frederick A. Beland , M. Matilde Marques , Cristina C. Jacob , Alexandra Maria Moita Antunes

Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients
TOXICOLOGY LETTERS, 260, 28-35 10 2016
Nadia M. Grilo , M. Joao Correia , Catarina Sequeira , Shrika G. Harjivan , Umbelina Caixas , Lucilia N. Diogo , M. Matilde Marques , Emilia C. Monteiro , Alexandra Maria Moita Antunes , Sofia A. Pereira

Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 82, 147-153 1 2016
Aline T. Marinho , Clara G. Dias , Pedro F. Pinheiro , Ana Rita Lemos , Alexandra Maria Moita Antunes , M. Matilde Marques , Emlia C. Monteiro , Joana P. Miranda , Sofia A. Pereira

Packing Interactions and Physicochemical Properties of Novel Multicomponent Crystal Forms of the Anti-Inflammatory Azelaic Acid Studied by X-ray and Solid-State NMR
CRYSTAL GROWTH \& DESIGN, 16, 154-166 1 2016
Ines C B Martins , Mariana Sardo , Sergio M. Santos , Auguste Femandes , Alexandra Maria Moita Antunes , Vânia André , Luis Mafra , M. Teresa Duarte

Selenium-Containing Chrysin and Quercetin Derivatives: Attractive Scaffolds for Cancer Therapy
JOURNAL OF MEDICINAL CHEMISTRY, 58, 4250-4265 5 2015
Inês Sofia Lança Martins , Catarina Sofia Romão Charneira , Valentina Gandin , João Ferreira da Silva , Gonçalo C. Justino , J. P. Telo , Abel J. S. C. Vieira , Cristina Marzano , Alexandra Maria Moita Antunes

Metabolic activation of the nevirapine metabolite 12-hydroxy-nevirapine to 12-formylnevirapine - A possible factor in nevirapine toxicity
TOXICOLOGY LETTERS, 238, S360-S361 10 2015
A. Godinho , G. Surratt , G. Gamboa da Costa , F. A. Beland , Alexandra Maria Moita Antunes , M. Matilde Marques

Protein adducts from carbamazepine-10,11-epoxide, the major metabolite of the antiepileptic drug carbamazepine: possible biomarkers of toxicity
TOXICOLOGY LETTERS, 238, S359 10 2015
Inês Sofia Lança Martins , M. Matilde Marques , Alexandra Maria Moita Antunes