Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP c
PHYTOMEDICINE, 23, 550-557 5 2016
Catarina Vizetto-Duarte , Luisa Custodio , KatkamN. Gangadhar , Joao Henrique G. Lago , Catarina Dias , Ana Marta Matos , Nuno Neng , J. M. F. Nogueira , Luisa Barreira , Fernando Albericio , Amélia P. Rauter , Joao Varela

Proximate biochemical composition and mineral content of edible species from the genus Cystoseira in Portugal
BOTANICA MARINA, 59, 251-257 8 2016
Catarina Vizetto-Duarte , Luisa Custodio , Luisa Barreira , M. M. da Silva , Amélia P. Rauter , Fernando Albericio , Joao Varela

Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds
PEERJ, 4, 2 2016
Catarina Vizetto-Duarte , Luisa Custodio , Gerardo Acosta , Joao H. G. Lago , Thiago R. Morais , Carolina Bruno de Sousa , Katkam N. Gangadhar , Maria Joao Rodrigues , Hugo Pereira , Raquel T. Lima , M. Helena Vasconcelos , Luisa Barreiro , Amélia P. Rauter , Fernando Albericioi , Joao Varela

Unravelling the antioxidant potential and the phenolic composition of different anatomical organs of the marine halophyte Limonium algarvense
INDUSTRIAL CROPS AND PRODUCTS, 77, 315-322 12 2015
Maria Joao Rodrigues , Ambre Soszynski , Alice Martins , Amélia P. Rauter , N. R. Neng , J. M. F. Nogueira , Joao Varela , Luisa Barreira , Luisa Custodio

New In Vitro Studies on the Bioprofile of Genista tenera Antihyperglycemic Extract
NATURAL PRODUCTS AND BIOPROSPECTING, 5, 277-285 12 2015
Daniela Batista , Pedro L. Fale , Maria L. Serralheiro , M. Eduarda Araújo , Paulo J. A. Madeira , Carlos Borges , Isabel Torgal , Margarida Goulart , Jorge Justino , Alice Martins , Amélia P. Rauter

Digestibility and Bioavailability of the Active Components of Erica australis L. Aqueous Extracts and Their Therapeutic Potential as Acetylcholinesterase Inhibitors
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, , 2015
Pilar Dias , Pedro L. Fale , Alice Martins , Amélia P. Rauter

Wittig Reaction: Domino Olefination and Stereoselectivity DFT Study. Synthesis of the Miharamycins Bicyclic Sugar Moiety
ORGANIC LETTERS, 17, 5622-5625 11 2015
Vasco Cachatra , Andreia Almeida , Joao Sardinha , Susana D. Lucas , Ana Gomes , P. D. Vaz , M. Helena Florencio , Rafael Nunes , Diogo Vila-Vicosa , Maria Jose Calhorda , Amélia P. Rauter

Fatty acid profile of different species of algae of the Cystoseira genus: a nutraceutical perspective
NATURAL PRODUCT RESEARCH, 29, 1264-1270 7 2015
Catarina Vizetto-Duarte , Hugo Pereira , Carolina Bruno de Sousa , Amélia P. Rauter , Fernando Albericio , Luisa Custodio , Luisa Barreira , Joao Varela

New antitumor 6-chloropurine nucleosides inducing apoptosis and G2/M cell cycle arrest
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 90, 595-602 1 2015
Stefan Schwarz , Bianka Siewert , Rene Csuk , Amélia P. Rauter

Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings
CHEMISTRY-A EUROPEAN JOURNAL, 21, 10513-10521 7 2015
Luca Unione , Bixue Xu , Dolores Diaz , Sonsoles Martin-Santamaria , Ana Poveda , Joao Sardinha , Amélia P. Rauter , Yves Bleriot , Yongmin Zhang , F. Javier Canada , Matthieu Sollogoub , Jesus Jimenez-Barbero

Botryococcus braunii and Nannochloropsis oculata extracts inhibit cholinesterases and protect human dopaminergic SH-SY5Y cells from H2O2-induced cytotoxicity
JOURNAL OF APPLIED PHYCOLOGY, 27, 839-848 4 2015
Luisa Custodio , Fernando Soares , Hugo Pereira , Maria Joao Rodrigues , Luisa Barreira , Amélia P. Rauter , Fernando Albericio , Joao Varela

Exploiting the Therapeutic Potential of 8-beta-D-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity, and Molecular Interaction with Islet Amyloid Polypeptide and Amyloid beta-Peptide (1-42)
JOURNAL OF MEDICINAL CHEMISTRY, 57, 9463-9472 11 2014
Ana R. Jesus , Catarina Dias , Ana M. Matos , R. F. M. de Almeida , A. Viana , Filipa Marcelo , Rogerio T. Ribeiro , Maria P. Macedo , Cristina Airoldi , Francesco Nicotra , Alice Martins , Eurico J. Cabrita , Jesus Jimenez-Barbere , Amélia P. Rauter

Antitumoural activity of Cystoseira species: Insights into the mechanism of action
PLANTA MEDICA, 80, 1358 11 2014
C. Vizetto-Duarte , M. J. Rodrigues , H. Pereira , N. R. Neng , J. M. F. Nogueira , H. Vasconcelos , G. Acosta , L. Custodio , Luisa Barreira , Amélia P. Rauter , F. Albericio , J. Varela

A natural approach: Synthesis and cytoxicity of monodesmosidic glycyrrhetinic acid glycosides
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 72, 78-83 1 2014
Stefan Schwarz , Bianka Siewert , Nuno Manuel Xavier , Ana R. Jesus , Amélia P. Rauter , Rene Csuk

Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 14, 1235-1243 2014
Nuno Manuel Xavier , Amélia P. Rauter

In vitro Antitumoral Activity of Compounds Isolated from Artemisia gorgonum Webb
PHYTOTHERAPY RESEARCH, 28, 1329-1334 9 2014
Alice Martins , Rukmini Mignon , Marina Bastos , Daniela Batista , N. R. Neng , J. M. F. Nogueira , Catarina Vizetto-Duarte , Luisa Custodio , Joao Varela , Amélia P. Rauter

Synthesis of Purine Nucleosides from D- Glucuronic Acid Derivatives and Evaluation of Their Cholinesterase- Inhibitory Activities
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 2770-2779 5 2014
Nuno Manuel Xavier , Stefan Schwarz , P. D. Vaz , Rene Csuk , Amélia P. Rauter

Fatty acid composition and biological activities of Isochrysis galbana T-ISO, Tetraselmis sp and Scenedesmus sp.: possible application in the pharmaceutical and functional food industries
JOURNAL OF APPLIED PHYCOLOGY, 26, 151-161 2 2014
Luisa Custodio , Fernando Soares , Hugo Pereira , Luisa Barreira , Catarina Vizetto-Duarte , Maria Joao Rodrigues , Amélia P. Rauter , Fernando Albericio , Joao Varela

Meeting report on EMBO Workshop: Glycobiology and glycochemistry, applications to human health and disease
GLYCOBIOLOGY, 24, 782-783 9 2014
Vanessa Ferreira , Celso A. Reis , Serge Perez , Amélia P. Rauter , Paula A. Videira

gem-Difluorocarbadisaccharides: Restoring the exo-Anomeric Effect
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 9597-9602 9 2014
Bixue Xu , Luca Unione , Joao Sardinha , Shaoping Wu , Melanie Etheve-Quelquejeu , Amélia P. Rauter , Yves Bleriot , Yongmin Zhang , Sonsoles Martin-Santamaria , Dolores Diaz , Jesus Jimenez-Barbero , Matthieu Sollogoub