Multifunctional iron- chelators with protective roles against neurodegenerative diseases
DALTON TRANSACTIONS, 42, 6058-6073 2013
Andreia Nunes , Sergio M. Marques , Catarina Quintanova , Diana F. Silva , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Hydroxypyri(mi)dine-Based Chelators as Antidotes of Toxicity Due to Aluminum and Actinides
CURRENT MEDICINAL CHEMISTRY, 19, 2773-2793 6 2012
M. Amélia Santos , M. Alexandra Esteves , Sílvia Chaves

Hydroxypyridinones as privileged chelating structures for the design of medicinal drugs
COORDINATION CHEMISTRY REVIEWS, 256, 240-259 1 2012
M. Amélia Santos , Sergio M. Marques , Sílvia Chaves

Hydroxy(thio)pyrone and hydroxy(thio)pyridinone iron chelators: Physico-chemical properties and anti-oxidant activity
JOURNAL OF INORGANIC BIOCHEMISTRY, 114, 38-46 9 2012
Sílvia Chaves , Sonia Canario , Marta P. Carrasco , Lurdes Mira , M. Amélia Santos

Novel Folate-Hydroxamate Based Antimetabolites: Synthesis and Biological Evaluation
MEDICINAL CHEMISTRY, 7, 265-274 7 2011
Marta P. Carrasco , Eva A. Enyedy , Natalia I. Krupenko , Sergey A. Krupenko , Elisa Nuti , Tiziano Tuccinardi , Salvatore Santamaria , Armando Rossello , Adriano Martinelli , M. Amélia Santos

Novel 1-Hydroxypiperazine-2,6-diones as New Leads in the Inhibition of Metalloproteinases
JOURNAL OF MEDICINAL CHEMISTRY, 54, 8289-8298 12 2011
Sergio M. Marques , Tiziano Tuccinardi , Elisa Nuti , Salvatore Santamaria , Vânia André , Armando Rossello , Adriano Martinelli , M. Amélia Santos

Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 26, 485-497 8 2011
Jaroslav Sebestik , Sergio M. Marques , Pedro L. Fale , Susana Santos , Daniela M. Arduino , Sandra M. Cardoso , Catarina R. Oliveira , Maria L. Serralheiro , M. Amélia Santos

Interaction of folic acid and some matrix metalloproteinase (MMP) inhibitor folate-gamma-hydroxamate derivatives with Zn(II) and human serum albumin
JOURNAL OF INORGANIC BIOCHEMISTRY, 105, 444-453 3 2011
Eva A. Enyedy , Etelka Farkas , Orsolya Doemoetoer , M. Amélia Santos

New hydroxypyridinone-functionalized sepharoses as sorbing agents for hard metal ions
JOURNAL OF HAZARDOUS MATERIALS, 186, 1902-1908 2 2011
Raquel Grazina , M. Amélia Santos

A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging solution and in vivo studies of Ga-67-labeled species
JOURNAL OF INORGANIC BIOCHEMISTRY, 105, 31-38 1 2011
Sílvia Chaves , Ana C. Mendonca , Sergio M. Marques , M. Isabel Prata , Ana C. Santos , Andre F. Martins , Carlos F. G. C. Geraldes , M. Amélia Santos

New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors (vol 20, pg 3623, 2010)
BIOORGANIC \& MEDICINAL CHEMISTRY LETTERS, 20, 7554 12 2010
M. Alexandra Esteves , Osvaldo Ortet , Anabela Capelo , Claudiu T. Supuran , Sergio M. Marques , M. Amélia Santos

Syntheses and characterization of Cu2+, Ni2+ and Zn2+ binding capability of histidinehydroxamic acid derivatives
POLYHEDRON, 29, 3137-3145 10 2010
Edit Csapo , Peter Buglyo , Nora Veronika Nagy , M. Amélia Santos , Alma Corona , Etelka Farkas

Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity
BIOORGANIC \& MEDICINAL CHEMISTRY, 18, 5081-5089 7 2010
Sergio M. Marques , Eva A. Enyedy , Claudiu T. Supuran , Natalia I. Krupenko , Sergey A. Krupenko , M. Amélia Santos

New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors
BIOORGANIC \& MEDICINAL CHEMISTRY LETTERS, 20, 3623-3627 6 2010
M. Alexandra Esteves , Osvaldo Ortet , Anabela Capelo , Claudiu T. Supuran , Sergio M. Marques , M. Amélia Santos

New Tris(hydroxypyridinones) as Iron and Aluminium Sequestering Agents: Synthesis, Complexation and In Vivo Studies
CHEMISTRY-A EUROPEAN JOURNAL, 16, 10535-10545 2010
Sílvia Chaves , Sergio M. Marques , Andre M. F. Matos , Andreia Nunes , Lurdes Gano , Tiziano Tuccinardi , Adriano Martinelli , M. Amélia Santos

Complexes of hydroxy(thio)pyrone and hydroxy(thio)pyridinone with Zn(II) and Mo(VI). Thermodynamic stability and insulin-mimetic activity
METALLOMICS, 2, 220-227 2010
Sílvia Chaves , Ratomir Jelic , Catarina Mendonca , Marta P. Carrasco , Yutaka Yoshikawa , Hiromu Sakurai , M. Amélia Santos

Combined chelation based on glycosyl-mono- and bis-hydroxypyridinones for aluminium mobilization: Solution and biodistribution studies
JOURNAL OF INORGANIC BIOCHEMISTRY, 103, 1521-1529 11 2009
Sílvia Chaves , Paul I. Dron , Florina A. Danalache , Diana Sacoto , Lurdes Gano , M. Amélia Santos

Multitemplate Alignment Method for the Development of a Reliable 3D-QSAR Model for the Analysis of MMP3 Inhibitors
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 49, 1715-1724 7 2009
Tiziano Tuccinardi , Gabriella Ortore , M. Amélia Santos , Sergio M. Marques , Elisa Nuti , Armando Rossello , Adriano Martinelli

New tripodal hydroxypyridinone based chelating agents for Fe(III), Al(III) and Ga(III): Synthesis, physico-chemical properties and bioevaluation
JOURNAL OF INORGANIC BIOCHEMISTRY, 103, 262-273 2 2009
Raquel Grazina , Lurdes Gano , Jaroslav Sebestik , M. Amélia Santos

Combined chelation of bi-functional bis-hydroxypiridinone and mono-hydroxypiridinone: Synthesis, solution and in vivo evaluation
JOURNAL OF INORGANIC BIOCHEMISTRY, 103, 288-298 2 2009
Sofia Gama , Marco Gil , Lurdes Gano , Etelka Farkas , M. Amélia Santos