Publications

Journal Article

Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21, 6 2020
Madalena Cipriano , Pedro F. Pinheiro , Catarina O. Sequeira , Joana S. Rodrigues , Nuno G. Oliveira , Alexandra Maria Moita Antunes , Matilde Castro , M. Matilde Marques , Sofia A. Pereira , Joana P. Miranda

Inducing the activity of NK cells with NKp30 small organic ligands
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256, 8 2018
Pedro F. Pinheiro , Goncalo Justino , Joana Miranda , M. Matilde Marques

Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study
ARCHIVES OF TOXICOLOGY, 91, 1199-1211 3 2017
Pedro F. Pinheiro , Sofia A. Pereira , Shrika G. Harjivan , Inês Sofia Lança Martins , Aline T. Marinho , Madalena Cipriano , Cristina C. Jacob , Nuno G. Oliveira , Matilde F. Castro , M. Matilde Marques , Alexandra Maria Moita Antunes , Joana P. Miranda

Synthesis, antimicrobial activity and toxicity to nematodes of cyclam derivatives
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 49, 646-649 5 2017
Luis G. Alves , Pedro F. Pinheiro , Joana R. Feliciano , Diana P. Damaso , Jorge H. Leitao , Ana M. Martins

3D in vitro cultures of human hepatocyte-like cells as an alternative competent model for nevirapine biotransformation studies
TOXICOLOGY LETTERS, 280, S263 10 2017
Madalena Cipriano , Pedro F. Pinheiro , Catarina Sequeira , Jorge M. Santos , Nuno G. Oliveira , Alexandra M. M. Antunes , M. Matilde Marques , Joana S. Rodrigues , Matilde Castro , Sofia A. Pereira , Joana P. Miranda

New small organic ligands for the natural cytotoxicity receptor NKp30
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 252, 8 2016
Pedro F. Pinheiro , Jose Justino , M. Marques

Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1
CHEMICAL BIOLOGY \& DRUG DESIGN, 88, 915-925 12 2016
Patricia S. Guerreiro , Silvia G. Estacio , F. J. N. Antunes , Ana S. Fernandes , Pedro F. Pinheiro , Joao G. Costa , Matilde Castro , Joana P. Miranda , Rita C. Guedes , Nuno G. Oliveira

Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 82, 147-153 1 2016
Aline T. Marinho , Clara G. Dias , Pedro F. Pinheiro , Ana Rita Lemos , Alexandra Maria Moita Antunes , M. Matilde Marques , Emlia C. Monteiro , Joana P. Miranda , Sofia A. Pereira

Camphor-based CCR5 blocker lead compounds - computational and experimental approach
RSC ADVANCES, 6, 56249-56259 2016
Gonçalo C. Justino , Pedro F. Pinheiro , Alexandra P. S. Roseiro , Ana S. O. Knittel , Joao Goncalves , Marta C. Justino , M Fernanda NN Carvalho

Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats
CHEMICO-BIOLOGICAL INTERACTIONS, 233, 115-121 5 2015
Pedro F. Pinheiro , A. T. Marinho , Alexandra Maria Moita Antunes , M. Matilde Marques , S. A. Pereira , Joana P. Miranda

Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts
TOXICOLOGY RESEARCH, 4, 1565-1577 2015
Shrika G. Harjivan , Pedro F. Pinheiro , Inês Sofia Lança Martins , Ana L. Godinho , Riccardo Wanke , P P Santos , Sofia A. Pereira , Frederick A. Beland , M. Matilde Marques , Alexandra Maria Moita Antunes

Role of epigenetic modifiers on human neonatal mesenchymal stem cells differentiation into hepatocyte-like cells
TOXICOLOGY LETTERS, 238, S187 10 2015
Madalena Cipriano , S. P. Camoes , S. Proenca , Pedro F. Pinheiro , R. N. Barcia , P. Cruz , Nuno G. Oliveira , M. Castro , Joana P. Miranda

Enzymatic bioactivation of the phenolic nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine to quinoid intermediates: Covalent adduct formation with nitrogen-based amino acids
TOXICOLOGY LETTERS, 238, S359-S360 10 2015
S. G. Harjivan , Pedro F. Pinheiro , Inês Sofia Lança Martins , D. A. Novais , R. Wanke , P P Santos , S. A. Pereira , F. A. Beland , M. Matilde Marques , Alexandra Maria Moita Antunes

PON-1 activity as a protective player in nevirapine hepatotoxicity: Data comparison in 2D and 3D cell cultures
TOXICOLOGY LETTERS, 229, S134-S135 9 2014
Aline T. Marinho , Clara G. Dias , Pedro F. Pinheiro , Alexandra Maria Moita Antunes , M. Matilde Marques , Emilia C. Monteiro , Joana P. Miranda , Sofia A. Pereira

Sex differences in hepatic and intestinal contributions for nevirapine biotransformation
TOXICOLOGY LETTERS, 229, S240-S241 9 2014
Pedro F. Pinheiro , Aline T. Marinho , Alexandra Maria Moita Antunes , M. Matilde Marques , Matilde F. Castro , Sofia A. Pereira , Joana P. Miranda

3D hepatocyte cultures: A useful tool in the study of Nevirapine bioactivation and toxicity
TOXICOLOGY LETTERS, 221, S174 8 2013
Joana P. Miranda , Pedro F. Pinheiro , A. T. Marinho , S. G. Harjivan , Matilde Castro , S. A. Pereira , Alexandra Maria Moita Antunes , M. Matilde Marques

Biochemical and Functional Studies on the Burkholderia cepacia Complex bceN Gene, Encoding a GDP-D-Mannose 4,6-Dehydratase
PLOS ONE, 8, 2 2013
Silvia A. Sousa , Joana R. Feliciano , Pedro F. Pinheiro , Jorge H. Leitao

Oxidation of phenolic nevirapine metabolites to a reactive quinone - a plausible pathway to toxicity
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 244, 8 2012
David A. Novais , Shrika G. Harjivan , Riccardo Wanke , Pedro F. Pinheiro , Pedro P. Santos , Frederick A. Beland , M. Matilde Marques , Alexandra Maria Moita Antunes

Synthesis and catalytic activity of camphor titanium complexes
INORGANICA CHIMICA ACTA, 383, 244-249 3 2012
M Fernanda NN Carvalho , Adelino M. Galvão , Jana Kredatusova , Jan Merna , Pedro F. Pinheiro , M. Margarida Salema

Distribution of Cepacian Biosynthesis Genes among Environmental and Clinical Burkholderia Strains and Role of Cepacian Exopolysaccharide in Resistance to Stress Conditions
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76, 441-450 1 2010
Ana S. Ferreira , Jorge H. Leitao , Ines N. Silva , Pedro F. Pinheiro , Silvia A. Sousa , Christian G. Ramos , Leonilde M. Moreira

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