Publication Type Journal Article
Title Synthesis of 2-arylpyrroles via catalytic dehydrogenation of 2-aryl-1-pyrrolines in the presence of palladium-supported on alumina
Authors Claudia A. Figueira Patrícia S. Lopes Pedro T. Gomes
Groups IOARC
Journal TETRAHEDRON
Year 2015
Month June
Volume 71
Number 25
Pages 4362-4371
Abstract A convenient synthesis of 2-arylpyrroles from the catalytic dehydrogenation of 2-aryl-1-pyrrolines in the presence of commercial palladium-supported on alumina (Pd/Al2O3) is described. The reaction scope was tested for aryl substituents with different steric hindrances and electronic natures. The dehydrogenation reaction conditions such as temperature, reflux time and amount of catalyst, revealed to be highly dependent on the 2-aryl substituent group, moderate to high yields and selectivities being obtained in a reaction involving straightforward work-up and purification procedures. In addition, the synthesis of the corresponding 2-aryl-1-pyrroline starting materials, through the cyclisation reaction involving 4-chlorobutyronitrile and aryl Grignard reagents, is also reported. (C) 2015 Elsevier Ltd. All rights reserved.
DOI http://dx.doi.org/10.1016/j.tet.2015.04.043
ISBN
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Book Title
ISSN 0040-4020
EISSN
Conference Name
Bibtex ID ISI:000356111100011
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