Publication Type |
Journal Article |
Title |
Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands |
Authors |
Ana Cristina Goncalves Tânia S. Morais M Paula Robalo Fernanda M. Marques Fernando Avecilla Cristina P. Matos Isabel Santos Ana Isabel Tomaz M. Helena Garcia |
Groups |
BioMol BIOIN |
Journal |
JOURNAL OF INORGANIC BIOCHEMISTRY |
Year |
2013 |
Month |
December |
Volume |
129 |
Number |
|
Pages |
1-8 |
Abstract |
Four new compounds of general formula [FeCp(dppe)L][CF3SO3] with L = imidazole substituted ligands, and dppe = ethylenebis(diphenylphosphane) have been synthesized and characterized with the aim to evaluate their anticancer properties. The new compounds were fully characterized by spectroscopic and electrochemical methods and the structure of [Fe(eta(5)-C5H5)(dppe)(1-BuIm)] [CF3SO3] (1), [Fe(eta(5)-C5H5)(dppe) (ImH)][CF3SO3] (3) and [Fe(eta(5)-C5H5)(dppe)(1HmIm)][CF3SO3] (4) (where 1-Bulm = 1-butylimidazole, and 1HmIm = N-hydroxymethylimidazole) was determined by X-ray diffraction studies. Apparently, these compounds are the first reported Fe(eta(5)-C5H5) half sandwich derivatives presenting high cytotoxic activity against a set a human tumor cell lines predicting their potential value as antitumor drugs. (C) 2013 Elsevier Inc. All rights reserved. |
DOI |
http://dx.doi.org/10.1016/j.jinorgbio.2013.07.033 |
ISBN |
|
Publisher |
|
Book Title |
|
ISSN |
0162-0134 |
EISSN |
1873-3344 |
Conference Name |
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Bibtex ID |
ISI:000327171500001 |
Observations |
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