Publication Type Journal Article
Title Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands
Authors Ana Cristina Goncalves Tânia S. Morais M Paula Robalo Fernanda M. Marques Fernando Avecilla Cristina P. Matos Isabel Santos Ana Isabel Tomaz M. Helena Garcia
Groups BioMol BIOIN
Journal JOURNAL OF INORGANIC BIOCHEMISTRY
Year 2013
Month December
Volume 129
Number
Pages 1-8
Abstract Four new compounds of general formula [FeCp(dppe)L][CF3SO3] with L = imidazole substituted ligands, and dppe = ethylenebis(diphenylphosphane) have been synthesized and characterized with the aim to evaluate their anticancer properties. The new compounds were fully characterized by spectroscopic and electrochemical methods and the structure of [Fe(eta(5)-C5H5)(dppe)(1-BuIm)] [CF3SO3] (1), [Fe(eta(5)-C5H5)(dppe) (ImH)][CF3SO3] (3) and [Fe(eta(5)-C5H5)(dppe)(1HmIm)][CF3SO3] (4) (where 1-Bulm = 1-butylimidazole, and 1HmIm = N-hydroxymethylimidazole) was determined by X-ray diffraction studies. Apparently, these compounds are the first reported Fe(eta(5)-C5H5) half sandwich derivatives presenting high cytotoxic activity against a set a human tumor cell lines predicting their potential value as antitumor drugs. (C) 2013 Elsevier Inc. All rights reserved.
DOI http://dx.doi.org/10.1016/j.jinorgbio.2013.07.033
ISBN
Publisher
Book Title
ISSN 0162-0134
EISSN 1873-3344
Conference Name
Bibtex ID ISI:000327171500001
Observations
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