Publication Type Journal Article
Title Multifunctional Small Molecules as Potential Anti-Alzheimer s Disease Agents
Authors Beatrice Bargagna Lidia Ciccone Susanna Nencetti M. Amélia Santos Sílvia Chaves Caterina Camodeca Elisabetta Orlandini
Groups BIOIN
Journal MOLECULES
Year 2021
Month
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Volume 26
Number 19
Pages
Abstract Alzheimer s disease (AD) is a severe multifactorial neurodegenerative disorder characterized by a progressive loss of neurons in the brain. Despite research efforts, the pathogenesis and mechanism of AD progression are not yet completely understood. There are only a few symptomatic drugs approved for the treatment of AD. The multifactorial character of AD suggests that it is important to develop molecules able to target the numerous pathological mechanisms associated with the disease. Thus, in the context of the worldwide recognized interest of multifunctional ligand therapy, we report herein the synthesis, characterization, physicochemical and biological evaluation of a set of five (1a-e) new ferulic acid-based hybrid compounds, namely feroyl-benzyloxyamidic derivatives enclosing different substituent groups, as potential anti-Alzheimer s disease agents. These hybrids can keep both the radical scavenging activity and metal chelation capacity of the naturally occurring ferulic acid scaffold, presenting also good/mild capacity for inhibition of self-A beta aggregation and fairly good inhibition of Cu-induced A beta aggregation. The predicted pharmacokinetic properties point towards good absorption, comparable to known oral drugs.
DOI http://dx.doi.org/10.3390/molecules26196015
ISBN
Publisher
Book Title
ISSN
EISSN 1420-3049
Conference Name
Bibtex ID WOS:000707033500001
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