Publication Type |
Journal Article |
Title |
Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms |
Authors |
M. Zegre J. Barros I. A. C. Ribeiro C. Santos L. A. Caetano L. Goncalves F. J. Monteiro M. P. Ferraz A. Bettencourt |
Groups |
CSSE |
Journal |
INTERNATIONAL JOURNAL OF PHARMACEUTICS |
Year |
2022 |
Month |
Notice: Undefined index: in /afs/ist.utl.pt/groups/cqe/web/tmp/templates_c/77f86a5f762542dadf50c7f7fefa96acd45c2726_0.file.paper.tpl.html.php on line 163
|
Volume |
622 |
Number |
|
Pages |
|
Abstract |
New strategies for the treatment of polymicrobial bone infections are required. In this study, the co-delivery of two antimicrobials by poly(D,L-lactic acid) (PDLLA) scaffolds was investigated in a polymicrobial biofilm model. PDLLA scaffolds were prepared by solvent casting/particulate leaching methodology, incorporating minocycline and voriconazole as clinically relevant antimicrobial agents. The scaffolds presented a sponge-like appearance, suitable to support cell proliferation and drug release. Single- and dual-species biofilm models of Staphylococcus aureus and Candida albicans were developed and characterized. S. aureus presented a higher ability to form singlespecies biofilms, compared to C. albicans. Minocycline and voriconazole-loaded PDLLA scaffolds showed activity against S. aureus and C. albicans single- and dual-biofilms. Ultimately, the cytocompatibility/functional activity of PDLLA scaffolds observed in human MG-63 osteosarcoma cells unveil their potential as a next-generation codelivery system for antimicrobial therapy in bone infections. |
DOI |
http://dx.doi.org/10.1016/j.ijpharm.2022.121832 |
ISBN |
|
Publisher |
ELSEVIER |
Book Title |
|
ISSN |
0378-5173 |
EISSN |
1873-3476 |
Conference Name |
|
Bibtex ID |
WOS:000810133900002 |
Observations |
|