Publication Type Journal Article
Title Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms
Authors M. Zegre J. Barros I. A. C. Ribeiro C. Santos L. A. Caetano L. Goncalves F. J. Monteiro M. P. Ferraz A. Bettencourt
Groups CSSE
Journal INTERNATIONAL JOURNAL OF PHARMACEUTICS
Year 2022
Month
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Volume 622
Number
Pages
Abstract New strategies for the treatment of polymicrobial bone infections are required. In this study, the co-delivery of two antimicrobials by poly(D,L-lactic acid) (PDLLA) scaffolds was investigated in a polymicrobial biofilm model. PDLLA scaffolds were prepared by solvent casting/particulate leaching methodology, incorporating minocycline and voriconazole as clinically relevant antimicrobial agents. The scaffolds presented a sponge-like appearance, suitable to support cell proliferation and drug release. Single- and dual-species biofilm models of Staphylococcus aureus and Candida albicans were developed and characterized. S. aureus presented a higher ability to form singlespecies biofilms, compared to C. albicans. Minocycline and voriconazole-loaded PDLLA scaffolds showed activity against S. aureus and C. albicans single- and dual-biofilms. Ultimately, the cytocompatibility/functional activity of PDLLA scaffolds observed in human MG-63 osteosarcoma cells unveil their potential as a next-generation codelivery system for antimicrobial therapy in bone infections.
DOI http://dx.doi.org/10.1016/j.ijpharm.2022.121832
ISBN
Publisher ELSEVIER
Book Title
ISSN 0378-5173
EISSN 1873-3476
Conference Name
Bibtex ID WOS:000810133900002
Observations
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