A new tripodal kojic acid derivative for iron sequestration: Synthesis, protonation, complex formation studies with Fe3+, Al3+, Cu2+ and Zn2+, and in vivo bioassays
JOURNAL OF INORGANIC BIOCHEMISTRY, 193, 152-165 4 2019
Valeria M. Nurchi , Maria de Guadalupe Jaraquemada-Pelaez , G. Crisponi , J. I. Lachowicz , Rosita Cappai , Lurdes Gano , M. Amélia Santos , Andrea Melchior , Marilena Tolazzi , M. Peana , Serenella Medici , Maria Antonietta Zoroddu

NMR spectroscopic, linear and non-linear optical properties of 1,3-benzothiazol-2-yl-(phenylhydrazono)acetonitrile (BTPA) azo dye
JOURNAL OF MOLECULAR STRUCTURE, 1179, 315-324 3 2019
H. M. Alsoghier , M. A. Selim , H. M. A. Salman , H. M. Rageh , M. Amélia Santos , S. A. Ibrahim , M. Dongol , T. Soga , A. A. Abuelwafa

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer s Disease
MOLECULES, 24, 2 2019
Rajeshwari Rajeshwari , Karam Chand , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Speciation Studies of Bifunctional 3-Hydroxy-4-Pyridinone Ligands in the Presence of Zn2+ at Different Ionic Strengths and Temperatures
MOLECULES, 24, 11 2019
Anna Irto , Paola Cardiano , Salvatore Cataldo , Karam Chand , Rosalia Maria Cigala , Francesco Crea , Concetta De Stefano , Giuseppe Gattuso , Nicola Muratore , Alberto Pettignano , Silvio Sammartano , M. Amélia Santos

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer s disease therapy
JOURNAL OF INORGANIC BIOCHEMISTRY, 179, 82-96 2 2018
Asha Hiremathad , Karam Chand , Lori Tolayan , Rajeshwari , Rangappa S. Keri , A. Raquel Esteves , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies
JOURNAL OF MEDICINAL CHEMISTRY, 61, 4421-4435 5 2018
Elisa Nuti , Doretta Cuffaro , Elisa Bernardini , Caterina Camodeca , Laura Panelli , Sílvia Chaves , Lidia Ciccone , Livia Tepshi , Laura Vera , Elisabetta Orlandini , Susanna Nencetti , Enrico A. Stura , M. Amélia Santos , Vincent Dive , Armando Rossello

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer s disease
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 148, 255-267 3 2018
Asha Hiremathad , Rangappa S. Keri , A. Raquel Esteves , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer s agents
NEW JOURNAL OF CHEMISTRY, 42, 16503-16515 10 2018
Sílvia Chaves , Asha Hiremathad , Daniel Tomás , Rangappa S. Keri , Luca Piemontese , M. Amélia Santos

Tacrine-deferiprone hybrids as multi-target-directed metal chelators against Alzheimer s disease: a two-in-one drug
METALLOMICS, 10, 1460-1475 10 2018
Karam Chand , Rajeshwari , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Development of a sensor for trivalent iron: AHP fixed on mesoporous silica
NEW JOURNAL OF CHEMISTRY, 42, 15237-15244 9 2018
Raffaela Biesuz , M. Amélia Santos , V. M. Nurchi , Giancarla Alberti

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer s drug candidates
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 33, 1212-1224 8 2018
Luca Piemontese , Daniel Tomás , Asha Hiremathad , Vito Capriati , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: synthesis, complexation and in vivo studies
NEW JOURNAL OF CHEMISTRY, 42, 8050-8061 5 2018
Rosita Cappai , Karam Chand , Joanna I. Lachowicz , Sílvia Chaves , Lurdes Gano , G. Crisponi , V. M. Nurchi , M. Peana , Maria Antonietta Zoroddu , M. Amélia Santos

A review on antioxidant potential of bioactive heterocycle benzofuran: Natural and synthetic derivatives
PHARMACOLOGICAL REPORTS, 69, 281-295 4 2017
Karam Chand , Rajeshwari , Asha Hiremathad , Mahak Singh , M. Amélia Santos , Rangappa S. Keri

Tacrine-allyl/propargylcysteine-benzothiazole trihybrids as potential anti-Alzheimer s drug candidates
RSC ADVANCES, 6, 53519-53532 2016
Asha Hiremathad , Karam Chand , A. Raquel Esteves , Sandra M. Cardoso , Rona R. Ramsay , Sílvia Chaves , Rangappa S. Keri , M. Amélia Santos

New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer s Disease
CHEMICAL BIOLOGY \& DRUG DESIGN, 87, 101-111 1 2016
Rangappa S. Keri , Catarina Quintanova , Sílvia Chaves , Diana F. Silva , Sandra M. Cardoso , M. Amélia Santos

Recent progress in repositioning Alzheimer s disease drugs based on a multitarget strategy
FUTURE MEDICINAL CHEMISTRY, 8, 2113-2142 11 2016
M. Amélia Santos , Karam Chand , Sílvia Chaves

Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer s agents: AChE inhibition, antioxidant activity and metal chelating capacity
JOURNAL OF INORGANIC BIOCHEMISTRY, 163, 266-277 10 2016
Karam Chand , Hesham M. Alsoghier , Sílvia Chaves , M. Amélia Santos

Recent progress in multifunctional metal chelators as potential drugs for Alzheimer s disease
COORDINATION CHEMISTRY REVIEWS, 327, 287-303 11 2016
M. Amélia Santos , Karam Chand , Sílvia Chaves

Copper(II) complexation of tacrine hybrids with potential anti-neurodegenerative roles
JOURNAL OF INORGANIC BIOCHEMISTRY, 151, 58-66 10 2015
Catarina Quintanova , Rangappa S. Keri , Sílvia Chaves , M. Amélia Santos

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 89, 340-348 1 2015
Olayiwola A. Adekoya , Stian Sjoli , Yimingjiang Wuxiuer , Irma Bilto , Sergio M. Marques , M. Amélia Santos , Elisa Nuti , Giovanni Cercignani , Armando Rossello , Jan-Olof Winberg , Ingebrigt Sylte