| Publication Type |
Journal Article |
| Title |
Copper complexes with a flexible piperazinyl arm: nuclearity driven catecholase activity and interactions with biomolecules |
| Authors |
Mriganka Das Poulami Mandal Novina Malviya Indrani Choudhuri Adilia Charmier Susana Morgado Shaikh M. Mobin Biswarup Pathak Suman Mukhopadhyay |
| Groups |
|
| Journal |
JOURNAL OF COORDINATION CHEMISTRY |
| Year |
2016 |
| Month |
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|
| Volume |
69 |
| Number |
24 |
| Pages |
3619-3637 |
| Abstract |
Three new Cu(II) complexes, [Cu(HL1)(pyridine)(H2O)](ClO4)(2)2MeOH (1), [Cu-2(HL1)(2)(NO3)(2)](NO3)(2)3H(2)O (2) and [Cu(HL2)(NO3)(2)]MeCN (3), have been synthesized from two Schiff base ligands [HL1=1-phenyl-3-((2-(piperazin-4-yl)ethyl)imino)but-1-en-1-ol and HL2=4-((2-(piperazin-1-yl)ethyl)imino)pent-2-en-2-ol] using the chair conformer of a flexible piperazinyl moiety. Structural analysis reveals that 1 and 3 are monomeric Cu(II) complexes consisting of five- and six-coordinate Cu(II), respectively, whereas 2 is a dinuclear Cu(II) complex consisting of two different Cu(II) centers, one square planar with the other distorted octahedral. Screening tests were conducted to quantify the binding of 1-3 towards DNA and BSA as well as the DNA cleavage activity of these complexes using gel electrophoresis. Enzyme kinetic studies were also performed for the complexes mimicking catecholase-like activities. Antibacterial activities of these complexes were also examined towards Methicillin-Resistant Staphylococcus aureus bacteria. The results reflect that 2 is more active than the monomeric complexes, which is further corroborated by density functional theory study. [GRAPHICS] . |
| DOI |
http://dx.doi.org/10.1080/00958972.2016.1236193 |
| ISBN |
|
| Publisher |
TAYLOR \& FRANCIS LTD |
| Book Title |
|
| ISSN |
0095-8972 |
| EISSN |
1029-0389 |
| Conference Name |
|
| Bibtex ID |
ISI:000387929400001 |
| Observations |
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