| Publication Type |
Journal Article |
| Title |
Vanadium Complexes as Prospective Therapeutics: Structural Characterization of a V-IV Lysozyme Adduct |
| Authors |
Marino F.A. Santos Isabel Correia Ana R. Oliveira Eugenio Garribba J.C. Pessoa Teresa Santos-Silva |
| Groups |
BIOIN |
| Journal |
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY |
| Year |
2014 |
| Month |
July |
| Volume |
|
| Number |
21 |
| Pages |
3293-3297 |
| Abstract |
The biological activity of vanadium complexes, namely, as insulin enhancers, is well known. We report a combined X-ray crystallography, electron paramagnetic resonance, and density functional theory study of the interaction of vanadium picolinate complexes with hen egg white lysozyme (HEWL). We show that the (VO)-O-IV(pic)(2) complex covalently binds to the COO- group of the side chain of Asp52 of HEWL. The long V-IV=O bond obtained in the X-ray study is explained to be due to reduction of V-IV to V-III during exposure of the crystals to the intense X-ray beam. |
| DOI |
http://dx.doi.org/10.1002/ejic.201402408 |
| ISBN |
|
| Publisher |
WILEY-V C H VERLAG GMBH |
| Book Title |
|
| ISSN |
1434-1948 |
| EISSN |
1099-0682 |
| Conference Name |
|
| Bibtex ID |
ISI:000339481400001 |
| Observations |
|
