||The development of cross-dehydrogenative coupling in recent years has simplified the
synthesis of many materials, as a result of facile C–H activation, which, together with its greater
atom economy and environmental friendliness, has made an impact on modern organic chemistry.
Indeed, many C–C and C–X (X = N, O, P, S, B, or Si) coupling reactions can now be performed
directly between two C–H bonds or a C–H and an X–H bond, simply by adding catalytic amounts
of a metal salt to a mixture of the two and an oxidant to accept the two hydrogen atoms released.
Chiral organocatalysts or chiral ligands have been joined to promote enantioselective processes,
resulting in the development of ecient reaction cascades that provide products in high yields and
high levels of asymmetric induction through cooperative catalysis. In recent years, photochemical
oxidation and electrochemistry have widened even more the scope of cross-dehydrogenative coupling
(CDC). In this review, we summarized the recent literature in this subject, hoping that it will inspire
many new synthetic strategies.