Publication Type |
Journal Article |
Title |
Synthesis of Substituted 4-Arylamine-1,2-naphthoquinones in One-Pot Reactions Using CotA-Laccase as Biocatalyst |
Authors |
Ana Catarina Cardoso de Sousa Iolanda Santos M. F. M. M. Piedade Ligia O. Martins M Paula Robalo |
Groups |
BioMol |
Journal |
ADVANCED SYNTHESIS \& CATALYSIS |
Year |
2020 |
Month |
August |
Volume |
362 |
Number |
16 |
Pages |
3380-3387 |
Abstract |
An efficient and environmentally benign biocatalytic strategy for the synthesis of substituted 4-arylamino-1,2-naphthoquinones was developed, through a cross-coupling reaction in which the 1,2-naphthoquinone nucleus, formed in the biocatalytic process mediated by CotA-laccase from Bacillus subtilis, is the key synthetic intermediate. Electrochemical data and kinetic parameters were determined revealing a significant higher specificity of CotA-laccase for 4-amino-3-hydroxynaphthalene-1-sulfonic acid (AHNSA). This ability of CotA-laccase to discriminate between oxidisable aromatic amines allows the set-up of one-pot reactions in the presence of the enzyme, between AHNSA and a set of appropriate aromatic amines under mild reaction conditions. |
DOI |
http://dx.doi.org/10.1002/adsc.202000082 |
ISBN |
|
Publisher |
WILEY-V C H VERLAG GMBH |
Book Title |
|
ISSN |
1615-4150 |
EISSN |
1615-4169 |
Conference Name |
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Bibtex ID |
ISI:000531345800001 |
Observations |
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