| Abstract |
This work reports for the first time the in vitro anti-oxidant (towards DPPH, ABTS, copper and iron), enzymatic inhibitory (on AChE, BuChE, alpha-glucosidase, alpha-amylase and tyrosinase), cytotoxicity (towards HepG2 and HEK 293 cells), and metabolomics (by HPLC-MS) of extracts from organs of Malcolmia littorea (L.) R.Br. Extracts were constituted mainly by phenolic acids and flavonoids, and main compounds were salicylic acid and luteolin-7-O-glucoside. Samples showed reduced radical scavenging and metal chelating capacity, and only the methanol extracts reduced iron. The root s ethanol and methanol extracts, and the aerial organ s ethanol extract exhibited the highest AChE inhibition. The root s ethanol extract displayed dual anti-cholinesterase activity. Samples showed a low capacity to inhibit alpha-amylase, but a high alpha-glucosidase inhibition was obtained with the root s and flower s ethanol extracts, and flower s methanol extract. Overall, samples displayed a high inhibition against tyrosinase, reduced HepG2 cellular viability and were less toxic towards HEK 293 cells. |
