Publication Type Journal Article
Title Heterogeneous Gold Nanoparticle-Based Catalysts for the Synthesis of Click-Derived Triazoles via the Azide-Alkyne Cycloaddition Reaction
Authors Ivy L. Librando Abdallah G. Mahmoud Sonia A. C. Carabineiro M. Fátima C. Guedes da Silva Francisco J. Maldonado-Hodar Carlos F. G. C. Geraldes Armando J.L. Pombeiro
Groups CCC
Year 2022
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Volume 12
Number 1
Abstract A supported gold nanoparticle-catalyzed strategy has been utilized to promote a click chemistry reaction for the synthesis of 1,2,3-triazoles via the azide-alkyne cycloaddition (AAC) reaction. While the advent of effective non-copper catalysts (i.e., Ru, Ag, Ir) has demonstrated the catalysis of the AAC reaction, additional robust catalytic systems complementary to the copper catalyzed AAC remain in high demand. Herein, Au nanoparticles supported on Al2O3, Fe2O3, TiO2 and ZnO, along with gold reference catalysts (gold on carbon and gold on titania supplied by the World Gold Council) were used as catalysts for the AAC reaction. The supported Au nanoparticles with metal loadings of 0.7-1.6\% (w/w relative to support) were able to selectively obtain 1,4-disubstituted-1,2,3-triazoles in moderate yields up to 79\% after 15 min, under microwave irradiation at 150 degrees C using a 0.5-1.0 mol\% catalyst loading through a one-pot three-component (terminal alkyne, organohalide and sodium azide) procedure according to the click rules. Among the supported Au catalysts, Au/TiO2 gave the best results.
Book Title
EISSN 2073-4344
Conference Name
Bibtex ID WOS:000746934300001
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